About the role
Mass spectrometry imaging (MSI) enables spatial characterization of the chemicals in biological tissues without the use of labels. MSI can help us better understand and diagnose diseases such as, for example, cancer. Most MSI is performed using ultraviolet (UV) lasers and an applied chemical matrix (matrix assisted laser desorption/ionization or MALDI). However, MALDI-MSI can also be performed using infrared (IR) lasers. IR-MALDI offers several advantages over UV-MALDI, such as the ability to use endogenous water in the tissue as the chemical matrix, which can reduce sample-preparation time, cost, and preparation-induced changes to the sample. Despite these advantages, IR-MALDI has remained less explored as a technology than UV-MALDI, in part because table-top IR laser systems have lacked the combination of wide frequency tunability and high pulse energy.
This PhD project seeks to adapt recent developments in UV-MALDI, namely MALDI-2 and transmission-mode MALDI, to IR-MALDI by utilizing the unique properties of the world-class infrared free-electron laser FELIX, in particular its high pulse energy and wide tunability. We will explore the unique chemical advantages that the FELIX laser provides to MALDI on a novel IR-MALDI source.
What you will do
In the first part of this project, you will work with the team at M4i, Maastricht University to design, develop, and test the novel IR-MALDI-MSI source. Then, in the next phase, you will install and operate this source at HFML-FELIX on a mass spectrometer coupled to the FELIX laser.
Along the way, you will develop and utilize a range of advanced skills, including imaging technologies design and simulation software, analytical and imaging methodologies, biological sample preparation, vacuum technology, laser operation and optics, and electrical and mechanical engineering. Furthermore, you are expected to present your work in scientific journals and at scientific conferences which will utilize skills such as technical writing, public speaking, and study of the current scientific literature base. You will also be able to gain experience teaching.
What you bring
- MSc in Chemistry, Physics, Chemical Engineering, Analytical Science and technology or a related subject involving lab experience with chemical/physics instrumentation
- Proficiency in spoken and written English (C1 or higher)
- Capacity to quickly acquire new knowledge and master new skills
- Interest and ability in hands-on research activities
- Ability to work both independently and as a member of a research team
- Problem solving skills and creativity
- A desire and ability to share your research through oral and written communication
- Other skills that would be helpful: Knowledge of scientific laser operation and laser optics, mass spectrometry imaging experience, knowledge of instrument control systems and software, ion beams and ion optics, programming
What we offer
- A challenging and meaningful position for 40 hours per week.
- A collegial team in which we help and support each other.
- A four-year PhD position, with a go/no-go decision to be made after a year and a half.
- A training program for PhD candidates at UM.
- A gross full-time monthly salary of €3,115, which will increase every year, in accordance with the salary scales for research trainees (OIOs) of the collective labour agreement for research institutions, plus holiday pay and a year-end bonus.
- Our excellent secondary employment conditions can be found here, such as the option to choose more than 8 weeks of holiday per year.
Would you like to know more?
For further information about this position, please contact Dr. Jonathan Martens (jonathan.martens@ru.nl), Dr. Ian Anthony (i.anthony@maastrichtuniversity.nl), or Prof. Ron Heeren (r.heeren@maastrichtuniversity.nl). For information about the application procedure, please contact Eileen Samshuijzen, HR advisor, telephone: 06 - 5103 2533, e-mail: eileen.samshuijzen@ru.nl. For more information about HFML-FELIX, see www.hfml-felix.nl.
Interested in applying?
Are you interested in this position? We would love to hear from you! You can apply until June 1, 2026 using the online application form below.
An assessment and online screening can be part of the application procedure.
Acquisition in response to this vacancy is not appreciated.
Diversity Code
HFML-FELIX is committed to a diverse workforce: we aim to foster talent and creativity by bringing together people from different backgrounds and cultures. We recruit and select candidates based on their skills and talents. We therefore encourage anyone who feels the role is a good fit to apply.
Who are we?
HFML-FELIX is a recognised research institute based in Nijmegen, where pioneering research is conducted into the properties and behaviour of (new) materials and molecules. This is achieved by exposing them to extreme conditions, including very high magnetic fields and powerful free-electron lasers. It is the only place in the world where these two techniques can be combined.
As an NWO research institute, HFML-FELIX is part of a large national collaboration consisting of Radboud University, NWO (the Dutch Organisation for Scientific Research) and six other Dutch universities. Our team consists of professors, scientists, technicians, office staff, postdocs, PhD students and students. This ensures a diverse and innovative working culture. We have our own HFML-FELIX Council and an International Scientific Advisory Committee.